Vasculitis
The Petechiae page has been updated, including some additional causes of vasculitis.
Haematology
Vitamin K and superwarfarins
The Warfarin page has been updated with additional information about the need for close monitoring following superwarfarin ingestion and the need for ongoing, tapering vitamin K therapy.
Aminocaproic acid removal
Aminocaproic acid has been removed from a variety of parts of the book as it is no longer available in Australia or New Zealand. Thanks to Stephanie for the suggestion.
Estimated total body iron deficit table
The Microcytic anaemia page has been updated, including the addition of an estimated total body iron deficit table.
Total body iron store replacement dose – correction
The Microcytic anaemia page has been corrected so the total body iron store replacement dose is now correct. It is: Total body iron deficit (mg) = body weight (kg) x (target Hb – actual Hb in g/L) x 0.24 + 500 mg For patients > 35 kg body weight.
D dimer
The Deep venous thrombosis page has been updated with some minor changes to the segment on D dimer.
FBE in leukaemia
The Leukaemia page has been updated with some additional information about the FBE in leukaemia.
Metamyelocytes in peripheral blood
The Blood film page has had a minor revision, including information about when metamyelocytes might be seen in peripheral blood.
Platelet counts in pregnancy
The Thrombocytopenia page has been updated with some additional information about platelet counts in normal pregnancy.
Febrile neutropenia
The Febrile neutropenia page has been updated with a variety of minor improvements, including the selective ordering of a CXR.
Doppler US images of DVT
The Deep venous thrombosis page has been updated with Doppler US images of normal and abnormal flow in suspected DVT.
Doppler US for DVT
The Deep venous thrombosis page has been updated, including the addition of short segments on Doppler US and the limitations of 2 region US.
Thrombolysis, clot retrieval and post phlebitic syndrome
The Management of DVT page has been updated with revised information about the role of thrombolysis and clot retrieval in the management of lower limb DVT.
Differential diagnosis of lower limb DVT
The Deep venous thrombosis page has been updated with additional information about how to differentiate a DVT from other causes of lower limb pain.
DOAC drug interactions
The Other anti-coagulants page has been updated with revised information about drug interactions with DOACs associated with increased bleeding risk.
ADAMTS 13 infusion for TTP
Information about recombinant ADAMTS 13 for the treatment of TTP has been added to the Thrombotic microangiopathies page.
PCC and DOAC reversal
The Reversal of anti-coagulation page has been updated, including more information about the role of PCC in reversal of DOACs
Prognostic features in TTP
The Thrombotic microangiopathies page has been updated with information about predictors of prognosis in TTP.
Anti-thrombotic therapy in thrombocytosis
The Thrombocytosis page has been updated with indications for aspirin therapy.
DOACs for valvular AF
The Stroke prevention in atrial fibrillation / flutter and Other anti-coagulants pages has been updated to indicate that DOACs are now thought to be safe for use in non-prosthetic valvular atrial fibrillation, with the exception of rheumatic mitral stenosis.