Non fasting lipids are OK

The Cardiovascular risk reduction page has been updated with the recommendation that fasting for lipid sampling is no longer required. Mora, S. Nonfasting for routine lipid testing: From evidence to action. JAMA Internal Medicine 2016.  

Anticoagulation in AF and ESRF

The Cerebrovascular disease page has been updated with revised information about anticoagulation for patients with AF and end stage renal failure. Dahal, K, Kunwar, S, Rijal, J, et al. Stroke, Major Bleeding, and Mortality Outcomes in Warfarin Users With Atrial Fibrillation and Chronic Kidney Disease: A Meta-Analysis of Observational Studies. Chest 2016;149(4):951-59. 

MRI for appendicitis

The Appendicitis page has been updated with new test characteristics of MRI. Petkovska, I, Martin, DR, Covington, MF, et al. Accuracy of Unenhanced MR Imaging in the Detection of Acute Appendicitis: Single-Institution Clinical Performance Review. Radiology 2016;279(2):451-60.  

Half strength apple juice for ORT

The Paediatric gastroenteritis page has been updated with information about the efficacy of half strength apple juice for ORT in children with only mild dehydration. Freedman, SB, Willan, AR, Boutis, K, et al. Effect of dilute apple juice and preferred fluids vs electrolyte maintenance solution on treatment failure among children with mild gastroenteritis: A randomized … Read more

Low dose tPA for stroke

Some information about low dose (0.6mg/kg) IV tPA for the treatment of stroke has been added to the Thrombolytic therapy in stroke page. Anderson, CS, Robinson, T, Lindley, RI, et al. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. N Engl J Med 2016.

Below knee DVT complication rates

The Management of DVT page has been updated with the rates of complications revised downwards from those previously quoted. Horner, D, Hogg, K, Body, R. Should we be looking for and treating isolated calf vein thrombosis? Emergency Medicine Journal 2016;33(6):431-37.

Don’t transfuse platelets to patients with ICH on antiplatelet agents

The Platelet transfusion and Stroke management pages have been updated with information from the PATCH RCT published in Lancet that demonstrated an increase in disability and mortality from platelet transfusion in patients with supratentorial ICH on mostly aspirin, clopidogrel and/or dipyridamole. The exact mechanism for this is unclear. Baharoglu, MI, Cordonnier, C, Salman, RA-S, et al. … Read more